Understanding Voltage Gating of Providencia stuartii Porins at Atomic Level

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Understanding Voltage Gating of Providencia stuartii Porins at Atomic Level

Bacterial porins are water-filled β-barrel channels that allow translocation of solutes across the outer membrane. They feature a constriction zone, contributed by the plunging of extracellular loop 3 (L3) into the channel lumen. Porins are generally in the open state, but undergo gating in response to external voltages. To date the underlying mechanism is unclear. Here we report results from m...

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ژورنال

عنوان ژورنال: PLOS Computational Biology

سال: 2015

ISSN: 1553-7358

DOI: 10.1371/journal.pcbi.1004255